A single dose cattle vaccine for healthy cattle four weeks of age or older that helps reduce disease associated with Moraxella bovis, the bacteria responsible for pinkeye. The cell free bacterin in an oil emulsion adjuvant provides protection that cross reacts with multiple pilus types. Administer 2 mL subcutaneously or intramuscularly in the neck 3 to 6 weeks before the onset of pinkeye season, with an annual booster recommended for continued protection.