A synthetic analogue of Maternal Bovine Appeasing Substance (mBAS™) designed to help reduce the perception of stress in cattle during management and physiological stressors. FerAppease can be used during weaning, dehorning, castration, branding, transportation, commingling, vaccination, parturition, dry-off, and breeding. For use only on healthy cattle, it is applied topically above the muzzle and in the divot behind the poll.